nicd (Cell Signaling Technology Inc)
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96
Structured Review
Cell Signaling Technology Inc
nicd
Nicd, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 96/100, based on 955 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/anti+nicd+antibody/Cleaved+Notch1+(Val1744)+Rabbit+mAb/pmc12975020-138-57-60
Average 96 stars, based on 955 article reviews
Nicd, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 96/100, based on 955 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/anti+nicd+antibody/Cleaved+Notch1+(Val1744)+Rabbit+mAb/pmc12975020-138-57-60
Average 96 stars, based on 955 article reviews
nicd - by Bioz Stars,
2026-09
96/100 stars
Images
1) Product Images from "Knockdown of Lymphoid Enhancer-binding Factor 1 Inhibits Pancreatic Adenocarcinoma Growth and Neoangiogenesis by Curbing Notch1 and Nuclear Factor Kappa B Signaling Pathways"
Article Title: Knockdown of Lymphoid Enhancer-binding Factor 1 Inhibits Pancreatic Adenocarcinoma Growth and Neoangiogenesis by Curbing Notch1 and Nuclear Factor Kappa B Signaling Pathways
Journal: Pancreas
doi: 10.1097/MPA.0000000000002562
Figure Legend Snippet: Knockdown of LEF1 interferes with PAAD cell malignant progression and neovascularization by inhibiting Notch1 and NF-κB signaling pathways. A–F, Immunofluorescence experiments and fluorescence intensity analysis: the relative fluorescence level of Notch1 and P65 decreased in AsPC-1/LEF1 and BxPC-3/LEF1. G–M, WB assay results and quantitative analysis: the total Notch1, NICD, Hes1, Hey1, and Jagged1 protein levels and the p-P65/P65 ratio were decreased in AsPC-1/LEF1 and BxPC-3/LEF1 (n = 3, * P <0.05).
Techniques Used: Knockdown, Protein-Protein interactions, Immunofluorescence, Fluorescence
Figure Legend Snippet: Knockdown of LEF1 enhances immune response in mice. A and B, Immunofluorescence results and percentage of positive cells: the fluorescence intensity of PD-L1 in tumor tissues of sh-LEF1 group decreased. C and D, HE staining results and necrotic cell count showed that the proportion of cell necrosis in sh-LEF1 tumor tissue was decreased. E–H, ELISA results and content statistics showed that knockdown of LEF1 downregulated the contents of TGF-β1, IL-10, PD-L1, and CCL2 in sh-LEF1 tumor tissues. I–O, WB assay results and quantitative analysis showed decreased levels of total Notch1, NICD, Hes1, Hey1, and Jagged1 proteins in tumor tissues, and a decreased p-P65/P65 ratio (n = 6, * P <0.05).
Techniques Used: Knockdown, Immunofluorescence, Fluorescence, Staining, Cell Characterization, Enzyme-linked Immunosorbent Assay
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